Cefadroxil (hydrate) (Synonyms: Duricef,Bidocel) |
| رقم الكتالوجGC16253 |
سيفادروكسيل (هيدرات) (BL-S 578 hydrate) هو الجيل الأول من السيفالوسبورين النشط عن طريق الفم مع نشاط واسع الطيف المضاد للبكتيريا.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66592-87-8
Sample solution is provided at 25 µL, 10mM.
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Cefadroxil is a new semisynthetic cephalosporin with a broad antibacterial spectrum and a high chemotherapeutic potential [1].
In vitro: The inhibitory activity of this compound was similar to that of cephalexin and cephradine when tested against 602 clinical isolates on Mueller-Hinton medium. In the oral treatment of experimental infections of mice, cefadroxil was more effective than cephalexin against Streptococcus pyogenes, and comparably effective against Streptococcus pneumoniae, Staphylococcus aureus, and several gram-negative species [1].
In vivo: In mice, oral administration of cefadroxil at doses ranging from 25 to 100 mg/kg attained peak concentrations in the blood. Higher peak levels were noted with cefadroxil than with cephalexin at a dose of 200 mg/kg [1].
Clinical trials: A single daily dose of cefadroxil appeared to be as effective in the treatment of patients with A β-hemolytic streptococcal (GABHS) pharyngitis [2].
References:
[1] Buck R E, Price K E. Cefadroxil, a new broad-spectrum cephalosporin[J]. Antimicrobial agents and chemotherapy, 1977, 11(2): 324-330.
[2] Gerber M A, Randolph M F, Chanatry J, et al. Once daily therapy for streptococcal pharyngitis with cefadroxil[J]. The Journal of pediatrics, 1986, 109(3): 531-537.
| Cas No. | 66592-87-8 | SDF | |
| المرادفات | Duricef,Bidocel | ||
| Chemical Name | (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrate | ||
| Canonical SMILES | OC1=CC=C([C@@H](N)C(N[C@@H]2C(N3[C@]2([H])SCC(C)=C3C(O)=O)=O)=O)C=C1.O | ||
| Formula | C16H17N3O5S • H2O | M.Wt | 381.4 |
| الذوبان | ≥ 5.8mg/mL in DMSO with gentle warming | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6219 mL | 13.1096 mL | 26.2192 mL |
| 5 mM | 0.5244 mL | 2.6219 mL | 5.2438 mL |
| 10 mM | 0.2622 mL | 1.311 mL | 2.6219 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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