(-)-Chaetominine (Synonyms: (-)-Chaetominine) |
رقم الكتالوجGC45246 |
(-) - شيتومينين هو مستقلب قلويد. (-) - شيتومينين له سمية خلوية ضد سرطان الدم البشري K562 وسرطان القولون SW1116. (-) - يقلل الشيتومينين من مقاومة العقاقير بوساطة MRP1 عن طريق تثبيط مسار إشارات PI3K / Akt / Nrf2 في خلايا سرطان الدم البشرية K562 / Adr.
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Cas No.: 918659-56-0
Sample solution is provided at 25 µL, 10mM.
(-)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (-)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.
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