Clitocine |
رقم الكتالوجGC60111 |
Clitocine ، وهو نظير نوكليوزيد الأدينوزين المعزول من الفطر ، هو عامل قراءة قوي وفعاليعمل الكليتوسين كقمع للطفرات غير المنطقية ويمكن أن يحفز إنتاج بروتين p53 في الخلايا التي تؤوي p53 أليلات طافرة لا معنى لهايمكن أن يحفز الكليتوسين موت الخلايا المبرمج في الخلايا السرطانية البشرية المقاومة للأدوية المتعددة عن طريق استهداف Mcl-1نشاط مضاد للسرطان
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Cas No.: 105798-74-1
Sample solution is provided at 25 µL, 10mM.
Clitocine, an adenosine nucleoside analog, is a potent and efficacious readthrough agent. Clitocine can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2].
Clitocine (0-0.8μM; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. Clitocine (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis[2].
Citocine (0.3-3 mg/kg; s.c.; five times per week)-induced p53 inhibits CAOV-33p53-UAA136 tumor growth in a xenograft model[1]. Animal Model: nu/nu mice (CAOV-3p53-UAA136 xenograft tumors)[1]
[1]. Friesen WJ, et al. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017;23(4):567-577. [2]. Sun JG, et al. Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation. Apoptosis. 2016;21(10):1144-1157.
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