Crebinostat |
رقم الكتالوجGC70432 |
Crebinostat هو مثبط فعال لهستون نازع الأستيلاز (HDAC) مع قيم IC50 من 0.7 نانومتر، 1.0 نانومتر، 2.0 نانومتر و 9.3 نانومتر لـ HDAC1، HDAC2، HDAC3 و HDAC6، على التوالي.
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Cas No.: 1092061-61-4
Sample solution is provided at 25 µL, 10mM.
Crebinostat (1 μM; 24 h) induces acetylation of AcH4K12 and AcH3K9 in mouse primary neuronal cells[1].
Crebinostat (1 μM; 24 h) downregulates Mapt mRNA expression, and upregulates Hspa1b (Hsp70) and Bdnf mRNA expression in mouse primary cultured neurons[1].
Crebinostat (1 μM; 24 h) increases histone acetylation and synapsin I punctae along dendrites in primary cultured neurons[1].
Crebinostat (25 mg/kg; IP; for 10 days) enhances memory of contextual fear conditioning in mice; induces an increase in total hippocampal acetylation of H4K12 and H3K9[1].
References:
[1]. Fass DM, et al. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 2013 Jan;64:81-96.
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