CTP Synthetase-IN-1 |
| رقم الكتالوجGC71196 |
يعتبر CTP Synthetase-IN-1 مثبط سيتيدين 5'-ثلاثي الفوسفات (CTPS) الفعال عن طريق الفم مع IC50s من 32 نانومتر و 18 نانومتر بالنسبة للبشر CTPS1 و CTPS2 على التوالي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2338811-71-3
Sample solution is provided at 25 µL, 10mM.
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CTP Synthetase-IN-1 (compound 27) inhibits rat CTPS1, rat CTPS2, mouse CTPS1, and mouse CTPS2 with IC50 values of 27 nM, 23 nM, 26 nM, and 33 nM, respectively[1].
CTP Synthetase-IN-1 (compound 27; 10-50 mg/kg; p.o; twice daily; for 18 days) shows significant pharmacological responses in collagen-induced arthritis (CIA) model[1].
References:
[1]. Andrew Novak, et al. Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem. 2022 Dec 22;65(24):16640-16650.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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