CU-T12-9 |
| رقم الكتالوجGC39285 |
CU-T12-9 هو ناهض TLR1 / 2 محدد مع EC50 من 52.9 نانومتر في اختبار HEK-Blue hTLR2 SEAP
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Cas No.: 1821387-73-8
Sample solution is provided at 25 µL, 10mM.
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CU-T12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS[1].
[1]. Cheng K, et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci Adv. 2015;1(3). pii: e1400139.
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