Dargistotug |
| رقم الكتالوجGC72322 |
Dargistotug (M-6223) هو جسم مضاد وحيد النسل من نوع IgG1 بشري بالكامل يستهدف TIGIT (مستقبل مناعي للخلية التائية مع نطاق Ig و ITIM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2649362-29-6
Sample solution is provided at 25 µL, 10mM.
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Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function.
References:
[1]. Harjunpää H, Guillerey C. TIGIT as an emerging immune checkpoint. Clin Exp Immunol. 2020 May;200(2):108-119.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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