DHODH-IN-1 |
| رقم الكتالوجGC70726 |
DHODH-IN-1 (المركب 18d) هو مثبط فعال نازع هيدروجين ثنائي الهيدروروتات (DHODH) مع IC50 من 25 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1800296-63-2
Sample solution is provided at 25 µL, 10mM.
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DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM)[1].
DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells[1].
DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules[1].
DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min[1].
References:
[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.
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