Disitertide (P144) |
| رقم الكتالوجGC34060 |
Disitertide (P144) (P144) عبارة عن مثبط هضمي لعامل النمو المحول بيتا 1 (TGF-β ؛ 1) مصمم خصيصًا لمنع التفاعل مع مستقبله. Disitertide (P144) (P144) هو أيضًا مثبط PI3K ومحفز موت الخلايا المبرمج.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 272105-42-7
Sample solution is provided at 25 µL, 10mM.
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Disitertide is an inhibitor of TGF-β1.
Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].
Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].
[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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