DPTIP |
| رقم الكتالوجGC50602 |
DPTIP هو مثبط قوي لسفينجوميليناز 2 (N-SMase 2) مخترق للدماغ (مثبط خارجي) ، مع IC50 من 30 نانومتر
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Cas No.: 351353-48-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.
Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID:30531925
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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