E3 Ligase Ligand-Linker Conjugates 20 (Synonyms: Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20) |
| رقم الكتالوجGC33390 |
يمكن استخدام E3 Ligase Ligand-Linker Conjugates 20 (Cereblon Ligand-Linker Conjugates 2) ، وهو اتحاد مركب E3 ligase ligand-linker الذي يشتمل على ترابط cereblon القائم على ثاليدوميد ورابط ، في توليف PROTACs.
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Cas No.: 1950635-15-0
Sample solution is provided at 25 µL, 10mM.
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E3 Ligase Ligand-Linker Conjugates 20 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand.
Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1].
[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
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