Eltanexor Z-isomer (Synonyms: KPT-8602 (Z-isomer)) |
| رقم الكتالوجGC19213 |
Eltanexor Z-isomer (KPT-8602 Z-isomer) هو الأيزومر الأقل نشاطًا لـ KPT-8602
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Cas No.: 1642300-78-4
Sample solution is provided at 25 µL, 10mM.
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KPT-8602 Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.IC50:In Vitro: KPT 8602 Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 uM, 30 uM, respectively[1]. In Vivo:
References:
[1]. Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.
[2]. Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21.
[3]. Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24.
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