Etilevodopa hydrochloride |
| رقم الكتالوجGC39757 |
يتحلل هيدروكلوريد Etilevodopa (L-Dopa ethyl ester) هيدروكلوريد ، وهو عقار أولي إيثيل إستر من Levodopa ، مائيًا سريعًا إلى Levodopa والإيثانول بواسطة إسترات غير محددة في الجهاز الهضمي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 39740-30-2
Sample solution is provided at 25 µL, 10mM.
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Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].
[1]. Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26(6):322-6. [2]. Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63(2):210-6. [3]. Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease. Molecules. 2017 Dec 25;23(1). pii: E40.
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