Facinicline hydrochloride (Synonyms: RG3487 hydrochloride) |
| رقم الكتالوجGC39748 |
هيدروكلوريد Facinicline (RG3487 hydrochloride) هو ناهض جزئي لمستقبل النيكوتين α7 النشط عن طريق الفم ، مع Ki من 6 نانومتر لـ α7 البشري nAChR
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Cas No.: 677305-02-1
Sample solution is provided at 25 µL, 10mM.
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Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM[1].
[1]. Tanya L Wallace, et al. RG3487, a Novel Nicotinic α7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents. J Pharmacol Exp Ther. 2011 Jan;336(1):242-53.
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