FAP-2286 |
| رقم الكتالوجGC65537 |
FAP-2286 ، وهو بروتين تنشيط البروتين الليفي (FAP) - الحلقة الكلية الببتيدية الملزمة إلى جانب مخلب النويدات المشعة DOTAيحتوي FAP-2286 على تقارب قوي مع بروتين FAP البشري بقيمة 1.1 نانومتريعتبر FAP-2286 ، عامل تصوير الورم ، أداة مفيدة للبحث في التصوير المقطعي بالإصدار البوزيتروني (PET)FAP-2286 له نشاط مضاد للورم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2581741-18-4
Sample solution is provided at 25 µL, 10mM.
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FAP-2286, a fibroblast activation protein (FAP)-binding peptidic macrocycle coupled to the radionuclide chelator DOTA. FAP-2286 has potent affinity to human FAP protein with a Kd of 1.1 nM. FAP-2286, a tumor imaging agent, is a useful tool for the research of positron emission tomography (PET). FAP-2286 has antitumor activity[1][2].
[1]. Dirk Zboralski, et al. Comparative Biodistribution and Radiotherapeutic Efficacy of the Fibroblast Activation Protein (FAP)-Targeting Agents FAP-2286 and FAPI-46.
[2]. Richard P Baum, et al. Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using 177 Lu-FAP-2286: First-in-Humans Results. J Nucl Med. 2022 Mar;63(3):415-423.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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