FAUC 346 |
| رقم الكتالوجGC62972 |
يُظهر FAUC 346 ، وهو ناهض جزئي D3 انتقائي للغاية (EC50 = 1.5 نانومتر) ، أيضًا تأثيرًا مثبطًا على سلوك البحث عن الكوكايين
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 474432-65-0
Sample solution is provided at 25 µL, 10mM.
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FAUC 346, a highly selective D3 partial agonist (EC50 = 1.5 nM), also demonstrates an inhibitory effect on cocaine-seeking behavior[1][2].
FAUC 346, an in vitro D3-selective ligand with a Ki of 0.23 nM in CHO cells for D3 receptor[1].FAUC346 shows some affinity for 5HT1A receptors (Ki = 41 nM) and for α1 receptors (Ki = 15 nM)[1].
[1]. Bertrand Kuhnast, et al. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide -- a potential radiotracer for D3 receptor imaging with PET. Nucl Med Biol. 2006 Aug;33(6):785-95.
[2]. Carsten Hocke, et al. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. ChemMedChem. 2008 May;3(5):788-93.
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