FKBP12 PROTAC dTAG-7 (Synonyms: dTAG-7) |
| رقم الكتالوجGC39289 |
FKBP12 PROTAC dTAG-7 (dTAG-7) عبارة عن مطهر متعدد الوظائفFKBP12 PROTAC dTAG-7 (dTAG-7) هو مذيب لـ FKBP12F36V مع تعبير عن FKBP12F36V في الإطار مع بروتين مهمFKBP12 PROTAC dTAG-7 (dTAG-7) هو أيضًا عامل إزالة انتقائي لمنشط BET bromodomain النسخي المنشط BRD4 عن طريق ربط BET bromodomains بـ E3 ubiquitin ligase CRBN
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Cas No.: 2064175-32-0
Sample solution is provided at 25 µL, 10mM.
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FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].
[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.
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