Fradafiban hydrochloride |
| رقم الكتالوجGC70223 |
Fradafiban hydrochloride هو مضاد بروتين سكري صفيحي غير ببتيدي IIb/IIIa، والذي يرتبط بمركب الصفيحة البشرية GP IIb/IIIa بقيمة Kd تبلغ 148 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Fradafiban hydrochloride is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban hydrochloride binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban hydrochloride reversibly binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM[1].
Fradafiban hydrochloride has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion[1].
References:
[1]. Müller TH, et al. Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997 Aug 19;96(4):1130-8.
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