Aristolactam I |
| رقم الكتالوجGC35388 |
Aristololactam I (AL-I) ، هو المستقلب الرئيسي لحمض الأرستولوكيك الأول (AA-I) ، ويشارك في العمليات التي تؤدي إلى تلف الكلى
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Cas No.: 13395-02-3
Sample solution is provided at 25 µL, 10mM.
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Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1].
[1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7.
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