Aspartyl-alanyl-diketopiperazine (Synonyms: DA-DKP) |
| رقم الكتالوجGC35410 |
Aspartyl-alanyl-diketopiperazine (DA-DKP) هو جزيء مناعي ناتج عن الانقسام والدوران من الطرف N للألبومين البشري ويمكن أن يعدل الاستجابة المناعية الالتهابية من خلال المسار الجزيئي المتورط في الحساسية اللمفاوية التائية
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Cas No.: 110954-19-3
Sample solution is provided at 25 µL, 10mM.
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Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy[1][2].
[1]. Bar-Or D, et al. Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin. Anal Biochem. 2013 Oct 1;441(1):13-7. [2]. Shimonkevitz R, et al. A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1. J Trauma. 2008 Jan;64(1):35-41.
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