Cucurbitacin IIa |
| رقم الكتالوجGC35758 |
Cucurbitacin IIa هو triterpene المعزول من Hemsleya amalils Diels ، ويحفز موت الخلايا المبرمج للخلايا السرطانية ، ويقلل من التعبير عن البقاء على قيد الحياة ، ويقلل من phospho-Histone H3 ويزيد PARP المشقوق في الخلايا السرطانية.
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Cas No.: 58546-34-2
Sample solution is provided at 25 µL, 10mM.
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Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells[1].
[1]. Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9.
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