ELQ-300 |
| رقم الكتالوجGC35974 |
ELQ-300 هو عامل مضاد للملاريا قوي ومتوفر بيولوجيًا ، يعمل كمثبط لموقع الاختزال (Qi) لمركب السيتوكروم bc1 (cyt bc1)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1354745-52-0
Sample solution is provided at 25 µL, 10mM.
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ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1)[1]. ELQ-300 sensitizes P. falciparum Dd2, Tm90-C2B, and D1 strains with IC50s of 6.6, 4.6 and 160 nM, respectively[1].
[1]. Stickles AM, et al. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum. Antimicrob Agents Chemother. 2015 Apr;59(4):1977-82.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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