Frentizole |
| رقم الكتالوجGC36076 |
Frentizole ، وهو مثبط مناعي معتمد من إدارة الغذاء والدواء ، هو مثبط تفاعل Aβ-ABAD (نازع هيدروجين الكحول المرتبط) بقيمة IC50 تبلغ 200 ميكرومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26130-02-9
Sample solution is provided at 25 µL, 10mM.
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Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.IC50 value:Target: Aβ-ABAD interaction
[1]. I I Scheetz ME, D G Carlson, and M R Schinitsky Frentizole, a novel immunosuppressive, and azathioprine: their comparative effects on host resistance to Pseudomonas aeruginosa, Candida albicans, herpes simplex virus, and influenza (Ann Arbor) virus. Infec [2]. Hatfield SM, Hartley LW, Schmidtke JR. The immunomodulatory action of frentizole, a novel immunosuppressive agent. Immunopharmacology. 1982 Dec;5(2):169-79. [3]. Xie, Yuli; Deng, Shixian; Chen, Zhenzhang et al. Identification of small-molecule inhibitors of the Aβ-ABAD interaction. Bioorganic & Medicinal Chemistry Letters (2006), 16(17), 4657-4660.
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