GLP-1R Antagonist 1 |
| رقم الكتالوجGC36148 |
GLP-1R Antagonist 1 (المركب 5d) هو مضاد فعال عن طريق الفم ، مخترق للجهاز العصبي المركزي وغير تنافسي لمستقبلات الببتيد 1 الشبيه بالجلوكاجون (GLP-1R) ، مع IC50 من 650 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 488097-06-9
Sample solution is provided at 25 µL, 10mM.
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GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1]. IC50: 650 nM (GLP-1R)[1].
[1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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