Indobufen |
| رقم الكتالوجGC36314 |
الإندوبوفين هو مثبط لتراكم الصفائح الدموية
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 63610-08-2
Sample solution is provided at 25 µL, 10mM.
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Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1]. COX
Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered[1].
[1]. Eligini S, et al. Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. Cardiovasc Res. 2006 Jan;69(1):218-26.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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