LXRβ agonist-2 |
رقم الكتالوجGC36499 |
LXRβ ؛ ناهض 2 هو ناهض لمستقبلات الكبد X (LXRβ) شديد الفعالية والانتقائية مع EC50 من 7 نانومتر ، ويعرض انتقائية 28.5 ضعفًا على LXRα (EC50 \u003d 200 نانومتر) ويستخدم في علاج تصلب الشرايين.
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Cas No.: 1949801-52-8
Sample solution is provided at 25 µL, 10mM.
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1]. EC50: 7 nM (LXRβ), 200 nM (LXRα)[1]
[1]. Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.
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