MK-2894 sodium salt |
| رقم الكتالوجGC36623 |
MK-2894 ملح الصوديوم هو مضاد قوي ، انتقائي ، فعال عن طريق الفم وذو تقارب عالي (Ki = 0.56 نانومتر) ضد مستقبل البروستانويد E 4 (مستقبل EP4) (IC50 = 2.5 نانومتر)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1006036-88-9
Sample solution is provided at 25 µL, 10mM.
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MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist.IC50 value:Target: EP4MK-2894 exhibits favorable pharmacokinetic profile in a number of preclinical species and potent anti-inflammatory activity in several animal models of pain/inflammation. MK-2894 also shows favorable GI tolerability profile in rats when compared to traditional NSAID indomethacin.
[1]. Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, LÉvesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O'Neill G, Ducharme Y, Friesen R. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluorometh
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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