NSC16168 |
| رقم الكتالوجGC36775 |
NSC16168 هو مثبط محدد لـ ERCC1-XPF ، بقيمة IC50 تبلغ 0.42 ميكرومتريمنع NSC16168 إصلاح الحمض النووي ويقوي فعالية CDDP في السرطان
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Cas No.: 6837-93-0
Sample solution is provided at 25 µL, 10mM.
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NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer[1]. IC50: 0.42 μM (ERCC1-XPF)[1].
[1]. Arora S, et al. Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells. Oncotarget. 2016 Nov 15;7(46):75104-75117.
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