PF-04937319 |
| رقم الكتالوجGC36881 |
PF-04937319 عبارة عن منشط للجلوكوكيناز (GKA) بقيمة EC50 تبلغ 154.4 ميكرومتر ، وهي واحدة من أكثر الاستراتيجيات الواعدة لعلاج داء السكري من النوع 2
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1245603-92-2
Sample solution is provided at 25 µL, 10mM.
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PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2]. EC50: 154.4 μM (GSA) (PF-04937319)[1]
[1]. Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072. [2]. Amin NB, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.
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