SNIPER(ER)-110 |
| رقم الكتالوجGC37657 |
يتكون SNIPER (ER) -110 من يجند IAP ورابط إستروجين ، متصلين بواسطة رابطيستحث SNIPER (ER) -51 تحلل بروتين مستقبلات هرمون الاستروجين (ER) مع DC50s أقل من 3 نانومتر و 7.7 نانومتر بعد 4 ساعات و 48 ساعة على التوالي
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Cas No.: 2241690-03-7
Sample solution is provided at 25 µL, 10mM.
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SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.
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