Swertiajaponin |
رقم الكتالوجGC37707 |
Swertiajaponin هو أحد مثبطات التيروزيناز ، ويشكل روابط هيدروجينية متعددة وتفاعلات كارهة للماء مع جيب الربط للتيروزيناز ، مع IC 50 من 43.47 ميكرومتر
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Cas No.: 6980-25-2
Sample solution is provided at 25 µL, 10mM.
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1]. IC50: 43.47 μM (tyrosinase)[1]
[1]. Lee B, et al. Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase. Oncotarget. 2017 Sep 15;8(56):95530-95541.
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