THIP |
| رقم الكتالوجGC37784 |
THIP (Gaboxadol) هو ناهض لمستقبلات GABAA الانتقائية خارج المشبك (eGABARs) (مع نفاذية حاجز الدم في الدماغ) ، ويظهر قيمة EC50 تبلغ 13 ميكرومتر لـ δ-GABAAR
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Cas No.: 64603-91-4
Sample solution is provided at 25 µL, 10mM.
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THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1]. α4β3δ GABAAR|13 μM (EC50)
[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.
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