Tuberculosis inhibitor 1 |
رقم الكتالوجGC37834 |
مثبط السل 1 هو مثبط قوي لنمو المثقبيات البروسي قوي وغير سام للخلايا مع EC50 من 5 نانومتر
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Cas No.: 2230810-28-1
Sample solution is provided at 25 µL, 10mM.
Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM[1]. EC50: 5 nM (Trypanosoma brucei)[1]
Tuberculosis inhibitor 1 is selective over other parasites, such as Trypanosoma cruzi and Plasmodium falciparum (T. cruzi EC50 8120 nM, P. falciparum EC50 3624 nM)[1].
[1]. Ferrigno F, et al. Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitorsof Trypanosoma brucei growth in vitro. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3689-3692.
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