Tubulysin D |
| رقم الكتالوجGC37838 |
Tubulysin D هو واحد من أقوى المشتقات بين tubulysins المعزولة من الأنواع المتفطرة الجيوفيزيائية Archangium geophyra و Angiococcus disciformisTubulysin D هو رباعي ببتيد جديد يعرض نشاطًا قويًا مضادًا للأورام ويؤدي إلى توقف دورة الخلية والاستماتة عن طريق تثبيط بلمرة توبولين باستخدام IC 50 من 1.7 ميكرومتريعرض Tubulysin نشاطًا قويًا سامًا للخلايا في خلايا الثدييات ، بما في ذلك خطوط الخلايا المقاومة للأدوية المتعددة ، مع قيم IC50 في النطاق النانوي السفلي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 309935-57-7
Sample solution is provided at 25 µL, 10mM.
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Tubulysin D is one of the most potent derivatives among the tubulysins isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin D is a novel tetrapeptide that displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. IC50: 1.7 μM (Tubulin)[1]
Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].
[1]. Shibue T, et al. Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. Bioorg Med Chem Lett. 2011 Jan 1;21(1):431-4. [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.
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