Vofopitant dihydrochloride (Synonyms: GR 205171A) |
| رقم الكتالوجGC37918 |
ثنائي هيدروكلوريد Vofopitant (GR 205171A) هو مضاد لمستقبلات تاكيكينين نيوروكينين 1 (NK1) قوي وانتقائي ومتوفر عن طريق الفم ، ويمنع ارتباط [3H] SP بمستقبل NK1 مع قيم pKi البالغة 9.5 و 10.6 في أغشية الفئران والأغشية البشرية على التوالي ، عامل محتمل مضاد للقيء واسع الطيف
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Cas No.: 168266-51-1
Sample solution is provided at 25 µL, 10mM.
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Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1]. pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]
[1]. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.
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