VP3.15 dihydrobromide |
| رقم الكتالوجGC37924 |
VP3.15 ثنائي هيدروبروميد هو مثبط قوي ومتوفر بيولوجيًا عن طريق الفم ويخترق الجهاز العصبي المركزي (PDE) 7- الجليكوجين سينثاز كيناز (GSK) 3 ، مع IC50s 1.59 ميكرومتر و 0.88 ميكرومتر لـ PDE7 و GSK-3 ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1281681-33-1
Sample solution is provided at 25 µL, 10mM.
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VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1]. IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]
[1]. Medina-RodrÍguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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