Shield-1 (Synonyms: Shld1) |
| رقم الكتالوجGC38060 |
Shield-1 (Shld1) هو مرتبط خاص وقابل للنفاذ إلى الخلية وعالي الانتماء ببروتين ربط FK506-12 (FKBP) ، ويعكس عدم الاستقرار عن طريق الارتباط بـ FKBP المحولة (mtFKBP) المتحولة ، مما يسمح بالتعبير المشروط عن بروتينات mtFKBP المدمجة.
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Cas No.: 914805-33-7
Sample solution is provided at 25 µL, 10mM.
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Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein[1][2].
[1]. Schoeber JP, et al. Conditional fast expression and function of multimeric TRPV5 channels using Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. [2]. Li S, et al. Effects of Shield1 on the viral replication of varicella zoster virus containing FKBP tagged ORF4and 48. Mol Med Rep. 2018 Jan;17(1):763-770.
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