DNA2 inhibitor C5 |
| رقم الكتالوجGC38207 |
يعتبر مثبط DNA2 C5 مثبطًا قويًا وتنافسيًا ومحددًا لنشاط نوكلياز DNA2 مع IC 50 بمقدار 20 ميكرومترمثبط DNA2 C5 يثبط نوكلياز ، ATPase المعتمد على الحمض النووي ، وهليكس ، وأنشطة ربط الحمض النووي لـ DNA2يعتبر مثبط الحمض النووي C5 مركبًا رئيسيًا واعدًا لتطوير محفزات للعلاجات الكيميائية للسرطان التي تسبب إجهاد النسخ المتماثل
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 35973-25-2
Sample solution is provided at 25 µL, 10mM.
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DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].
[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.
| Cas No. | 35973-25-2 | SDF | |
| Canonical SMILES | O=C(C1=C(O)C2=CC=CC([N+]([O-])=O)=C2N=C1)O | ||
| Formula | C10H6N2O5 | M.Wt | 234.17 |
| الذوبان | DMSO: 31.25 mg/mL (133.45 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.2704 mL | 21.352 mL | 42.704 mL |
| 5 mM | 0.8541 mL | 4.2704 mL | 8.5408 mL |
| 10 mM | 0.427 mL | 2.1352 mL | 4.2704 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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