ASLAN003 (Synonyms: ASLAN003) |
| رقم الكتالوجGC38463 |
ASLAN003 (ASLAN003) هو مثبط فعال عن طريق الفم وفعال لنزع هيدروجين ثنائي هيدروجين (DHODH) مع IC50 من 35 نانومتر لإنزيم DHODH البشري. ASLAN003 يثبط تخليق البروتين عن طريق تنشيط عوامل النسخ AP-1. ASLAN003 يحث على موت الخلايا المبرمج ويطيل بشكل كبير البقاء على قيد الحياة في الفئران xenograft ابيضاض الدم النخاعي الحاد (AML).
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Cas No.: 1035688-66-4
Sample solution is provided at 25 µL, 10mM.
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ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) which has the potential to be a first-in-class candidate in AML (Acute Myelogenous Leukemia). ASLAN003 has antitumor activity[1].
[1]. Marco L. Lolli, et al. Human Dihydroorotate Dehydrogenase (hDHODH) as a new target on Acute Myelogenous Leukemia (AML): Targeting Myeloid Differentiation using Potent and Innovative hDHODH Inhibitors. 23rd Swedish Conference on Macromolecular Structure and Function TÄllberg, 14-17 June 2019
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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