GLP-2 (rat) (trifluoroacetate salt) (Synonyms: Glucagon-like Peptide 2) |
| رقم الكتالوجGC45464 |
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Glucagon-like peptide 2 (GLP-2) is a gut peptide hormone antagonist of the GLP-2 receptor (GLP-2R; Ki = 60 pM).1 It increases cAMP levels in COS cells expressing GLP-2R with an EC50 value of 0.58 nM. GLP-2 is primarily produced by enteroendocrine L cells of the small and large intestine but can also be found in the hypothalamus.1,2 In vivo, GLP-2 (43.75 μg twice per day for 10 days) increases small bowel weight by 50% and increases villus height and crypt cell proliferation in the small intestine in mice.3 GLP-2 (10 μg per animal) reduces two-hour food intake in rats by 37% with no reduction in water intake.2 Secretion of GLP-2 in rats is stimulated by dietary carbohydrates, glucose, dextrin, and oils rich in polyunsaturated or monounsaturated fatty acids.4
References
1. Munroe, D.G., Gupta, A.K., Kooshesh, F., et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl. Acad. Sci. U.S.A. 96(4), (1999).
2. Tang-Christensen, M., Larsen, P.J., Thulesen, J., et al. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat. Med. 6(7), 802-807 (2000).
3. Drucker, D.J., Erlich, P., Asa, S.L., et al. Induction of intestinal epithelial proliferation by glucagon-like peptide 2. Proc. Natl. Acad. Sci. U.S.A. 93(15), 7911-7916 (1996).
4. Sato, S., Hokari, R., Kurihara, C., et al. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion. Am. J. Physiol Gastrointest. Liver Physiol. 304(8), 304-308 (2013).
| Cas No. | SDF | ||
| المرادفات | Glucagon-like Peptide 2 | ||
| Canonical SMILES | OC([C@]1([2H])CCC([2H])([2H])N1C([C@H](C)CS)=O)=O | ||
| Formula | C166H256N44O56S.XCF3COOH | M.Wt | 3796.1 |
| الذوبان | Formic Acid: 1 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.2634 mL | 1.3171 mL | 2.6343 mL |
| 5 mM | 0.0527 mL | 0.2634 mL | 0.5269 mL |
| 10 mM | 0.0263 mL | 0.1317 mL | 0.2634 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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