الصفحة الرئيسية>>MRS 2395

MRS 2395

رقم الكتالوجGF07355

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MRS 2395 التركيب الكيميائي

Cas No.: 491611-55-3

الحجم السعر المخزون الكميّة
5mg
797٫00
متوفر

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  • GlpBio Citations

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products
MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. MRS2395 inhibits ADP-induced platelet activation with a Ki of 3.6 渭M. MRS2395 inhibits cAMP induced by ADP in rat platelets in the presence of PGE1 with an IC50 of 7 碌M. MRS2395 enhances platelet dense granule release in response to TRAP-6.

[1]. Bin Xu, et al.Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation. J Med Chem. 2002 Dec 19;45(26):5694-709.  

[2]. Annachiara Mitrugno, et al. Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y 12 signaling with MRS2395. Platelets. 2018 Jun;29(4):383-394. 

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