GFB-8438 |
| رقم الكتالوجGC39488 |
GFB-8438 هو مثبط TRPC5 قوي وفرعي انتقائي ، مع IC50s من 0.18 و 0.29 ميكرومتر من hTRPC5 و hTRPC4 ، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2304549-73-1
Sample solution is provided at 25 µL, 10mM.
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GFB-8438 is a potent and subtype selective TRPC5 inhibitor, with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model[1].
[1]. Yu M, et al.Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.ACS Med Chem Lett. 2019 Oct 22;10(11):1579-1585.
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