Glabrescione B |
| رقم الكتالوجGC62043 |
Glabrescione B هو أول مركب يربط Hedgehog (Hh) المغير Gli1يضعف Glabrescione B نشاطه عن طريق التدخل في تفاعل Gli1-DNAيمنع Glabrescione B نمو الخلايا السرطانية المعتمدة على القنفذ ، والقدرة على التجديد الذاتي ، واستنساخ الخلايا الجذعية المشتقة من الورم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65893-94-9
Sample solution is provided at 25 µL, 10mM.
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Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].
Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma[2].Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels[2].
[1]. Ingallina C, et al. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine (Lond). 2017;12(7):711-728.
[2]. Infante P, et al. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J. 2015;34(2):200-217.
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