GLL398 (Synonyms: GLL398; GLL-398; GLL 398.) |
| رقم الكتالوجGB62180 |
GLL398 is an Oral Selective Estrogen Receptor Downregulator.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2077980-83-5
Sample solution is provided at 25 µL, 10mM.
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GLL398 is an Oral Selective Estrogen Receptor Downregulator. GLL398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1.14 nM) and potently degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). Most importantly, the introduction of the boronic acid group confers superior oral bioavailability of GLL398 (AUC = 36.9 μg.h/mL) in rats as compared to GW7604 (AUC = 3.35 μg.h/mL). The strikingly favorable pharmacokinetic property of GLL398 makes it a promising oral SERD suitable for clinical evaluation.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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