GPR139 agonist-2 |
رقم الكتالوجGC71095 |
GPR139 agonist-2 (المركب 20a) هو ناهض قوي GPR139 مع EC50 من 24.7 نانومتر.
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Cas No.: 2983118-29-0
Sample solution is provided at 25 µL, 10mM.
GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research.
References:
[1]. Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66(20):14011-14028.
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