GRL-0496 |
رقم الكتالوجGC62221 |
GRL-0496 هو أحد مثبطات SARS-CoV 3CLpro المشتقة من إستر الكلورووبيريديل ، مع IC 50 من 30 نانومتر في كل من مثبطات الإنزيم والمقايسات المضادة للفيروسات
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1087243-14-8
Sample solution is provided at 25 µL, 10mM.
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].
GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].
[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.
Average Rating: 5
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