الصفحة الرئيسية>>Signaling Pathways>> Others>> Adenylate cyclase>>Guanylyl Imidodiphosphate

Guanylyl Imidodiphosphate (Synonyms: Guanosine 5'-[β,γ-imido]triphosphate trisodium)

رقم الكتالوجGC13248

جوانيليميدوديفوسفات (غوانوزين 5'- [β،γ-إميدو] ثلاثي الفوسفات) ثلاثية الصوديوم هي مشتق GTP غير قابل للهضم، وهى منشط لعامل تركيل ADP-ribosylation (ARF) وحافز قوى لأدينيلات سايكلاز.

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Guanylyl Imidodiphosphate التركيب الكيميائي

Cas No.: 148892-91-5

الحجم السعر المخزون الكميّة
1mg
65٫00
متوفر
5mg
192٫00
متوفر
10mg
352٫00
متوفر
25mg
714٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of Guanylyl Imidodiphosphate

Guanylyl imidodiphosphate is a nonhydrolyzable analog of GTP that can bind to and irreversibly activate G proteins in the presence of Mg2+.[1] This nucleotide is a potent stimulator of adenylate cyclase.[2] Guanylyl imidodiphosphate is used in studies of protein synthesis since the process of GTP binding, hydrolysis, and release is essential for the initiation of protein translocation across the endoplasmic reticulum.[3]

Reference:
[1]. Terry, B.J., and Purich, D.L. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. The Journal of Biological Chemisty 255(21), 10532-10536 (1980).
[2]. Lefkowitz, R.J., and Caron, M.G. Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. The Journal of Biological Chemisty 250(12), 4418-4422 (1975).
[3]. Rapoport, T.A. Transport of proteins across the endoplasmic reticulum membrane. Science 258(5084), 931-936 (1992).

Chemical Properties of Guanylyl Imidodiphosphate

Cas No. 148892-91-5 SDF
المرادفات Guanosine 5'-[β,γ-imido]triphosphate trisodium
Chemical Name 5’-guanylic acid, monoanhydride with imidodiphosphoric acid, tetralithium salt
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@H](COP(OP(NP(O)([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+]
Formula C10H14N6O13P3 • 3Na M.Wt 588.1
الذوبان 10mg/ml in PBS (pH7.2) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Guanylyl Imidodiphosphate

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.7004 mL 8.502 mL 17.0039 mL
5 mM 0.3401 mL 1.7004 mL 3.4008 mL
10 mM 0.17 mL 0.8502 mL 1.7004 mL
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In vivo Formulation Calculator (Clear solution) of Guanylyl Imidodiphosphate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 8 reference(s) in Google Scholar.)

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