HBF-0259 |
| رقم الكتالوجGC63003 |
HBF-0259 هو مثبط قوي وانتقائي لمستضد سطح فيروس التهاب الكبد B (HBV) لإفراز مستضد سطح (HBsAg) ، مع EC50 من 1.5 ميكرومتر في خلايا HepG2.2.15
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 957011-15-3
Sample solution is provided at 25 µL, 10mM.
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HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis[1][2].
HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC50=1.5 μM) in HepDE19 cells, with an CC50 of >50 μM[1].HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells[1].
[1]. Dougherty AM, et, al. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51(12):4427-37.
[2]. Yu W, et, al. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54(16):5660-70.
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