HMR 1556 |
| رقم الكتالوجGC34616 |
HMR 1556 ، مشتق من الكرومانول ، هو مانع قوي لـ IKs مع ICs من 10.5 نانومتر و 34 نانومتر في عضلات البطين الأيسر من الكلاب وخنازير غينيا ، على التوالي
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Cas No.: 223749-46-0
Sample solution is provided at 25 µL, 10mM.
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HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2]. IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1]
HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1].
[1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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