HUP-55 |
| رقم الكتالوجGC91099 |
مثبط لإنزيم برويل إندوبيبتيداز
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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HUP-55 is an inhibitor of prolyl endopeptidase (IC50 = 5 nM).1 It reduces α-synuclein dimerization in Neuro2a cells, induces autophagy in HEK293 cells, and decreases drogen peroxide-induced increases in reactive oxygen species (ROS) production in SH-SY5Y cells when used at a concentration of 10 µM. HUP-55 (10 mg/kg) decreases ipsilateral paw use and striatal oligomeric α-synuclein levels in a mouse model of Parkinson’s disease induced by adenoviral delivery of an α-synuclein-encoding vector (AAV-αSyn).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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